The fic domain: regulation of cell signaling by adenylylation.

  title={The fic domain: regulation of cell signaling by adenylylation.},
  author={Carolyn A. Worby and Seema Mattoo and Robert P. Kruger and Lynette B. Corbeil and Antonius A. Koller and Juan Camilo M{\'e}ndez and Bereket Zekarias and Cheri S. Lazar and Jack E. Dixon},
  journal={Molecular cell},
  volume={34 1},
We show that the secreted antigen, IbpA, of the respiratory pathogen Histophilus somni induces cytotoxicity in mammalian cells via its Fic domains. Fic domains are defined by a core HPFxxGNGR motif and are conserved from bacteria to humans. We demonstrate that the Fic domains of IbpA catalyze a unique reversible adenylylation event that uses ATP to add an adenosine monophosphate (AMP) moiety to a conserved tyrosine residue in the switch I region of Rho GTPases. This modification requires the… CONTINUE READING


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