The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate.

@article{Rhijn2001TheFG,
  title={The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate.},
  author={Bas Wilhelmus Gerardus van Rhijn and Irene Lurkin and François Radvanyi and Wim J. Kirkels and Theodorus H van der Kwast and Ellen C. Zwarthoff},
  journal={Cancer research},
  year={2001},
  volume={61 4},
  pages={1265-8}
}
We analyzed the possible prognostic value of the recently discovered fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer. A FGFR3 mutation was found in 34 of 53 pTaG1-2 bladder cancers, whereas none of the 19 higher-staged tumors had a mutation (P < 0.0001). In 57 patients with superficial disease followed prospectively by cystoscopy for 12 months, 14 of 23 patients in the wild-type FGFR3 group developed recurrent bladder cancer compared with only 7 of 34 patients in the… CONTINUE READING
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Molecular evolution of multiple recurrent cancers of the bladder

  • A.A.G. Van Tilborg, A. de Vries, M. de Bont, L. E. Groenfeld, T. H. van der Kwast, E. C. Zwarthoff
  • Hum. Mol. Genet.,
  • 2000

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