The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).

@article{Shavkunov2013TheFG,
  title={The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).},
  author={Alexander S. Shavkunov and Norelle C Wildburger and Miroslav N. Nenov and Thomas F James and Tetyana P Buzhdygan and Neli I. Panova-Elektronova and Thomas A. Green and Ronald L. Veselenak and Nigel Bourne and Fernanda Laezza},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 27},
  pages={19370-85}
}
The FGF14 protein controls biophysical properties and subcellular distribution of neuronal voltage-gated Na(+) (Nav) channels through direct binding to the channel C terminus. To gain insights into the dynamic regulation of this protein/protein interaction complex, we employed the split luciferase complementation assay to screen a small molecule library of kinase inhibitors against the FGF14·Nav1.6 channel complex and identified inhibitors of GSK3 as hits. Through a combination of a… CONTINUE READING
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