The fibroblast: Sentinel cell and local immune modulator in tumor tissue

@article{Silzle2004TheFS,
  title={The fibroblast: Sentinel cell and local immune modulator in tumor tissue},
  author={Tobias Silzle and Gwendalyn J. Randolph and Marina Kreutz and Leoni A. Kunz-Schughart},
  journal={International Journal of Cancer},
  year={2004},
  volume={108}
}
Development and progression of epithelial malignancies are frequently accompanied by complex phenotypic alterations of resident tissue fibroblasts. Some of these changes, such as myofibroblastic differentiation and an oncofetal extracellular matrix (ECM) expression profile, are also implicated in inflammation and tissue repair. Studies over the past decade revealed the relevance of reciprocal interactions between tumor cells and tumor‐associated host fibroblasts (TAF) in the malignant process… 
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