The fibrinogen globe of tenascin-C promotes basic fibroblast growth factor-induced endothelial cell elongation.

@article{Schenk1999TheFG,
  title={The fibrinogen globe of tenascin-C promotes basic fibroblast growth factor-induced endothelial cell elongation.},
  author={Susanne H. Schenk and Ruth Chiquet-Ehrismann and Edouard J. Battegay},
  journal={Molecular biology of the cell},
  year={1999},
  volume={10 9},
  pages={
          2933-43
        }
}
To investigate the potential role of tenascin-C (TN-C) on endothelial sprouting we used bovine aortic endothelial cells (BAECs) as an in vitro model of angiogenesis. We found that TN-C is specifically expressed by sprouting and cord-forming BAECs but not by nonsprouting BAECs. To test whether TN-C alone or in combination with basic fibroblast growth factor (bFGF) can enhance endothelial sprouting or cord formation, we used BAECs that normally do not sprout and, fittingly, do not express TN-C… CONTINUE READING

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