The ferroportin disease.

  title={The ferroportin disease.},
  author={Antonello Pietrangelo},
  journal={Blood cells, molecules & diseases},
  volume={32 1},
A new inherited disorder of iron metabolism, hereafter called "the ferroportin disease," is increasingly recognized worldwide. The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not linked to the hemochromatosis (HFE) gene. It has distinctive clinical features such as early increase in serum ferritin in spite of low-normal… CONTINUE READING