The feed-back regulation of erythropoietin production in healthy humans.

@article{Klausen1998TheFR,
  title={The feed-back regulation of erythropoietin production in healthy humans.},
  author={Tom Klausen},
  journal={Danish medical bulletin},
  year={1998},
  volume={45 4},
  pages={345-53}
}
The proposed oxygen-dependent feed-back loop regulation of EPO production (Fogh 1978, Erslev 1991, LeHir et al 1991, Nielsen 1991) is mainly supported by data from studies in animals and cell cultures. The feed-back loop and its dependence on oxygen was therefore challenged by studies in healthy humans: Exposure of humans to different levels of acute and continued altitude hypobaria provided evidence for an oxygen dependency of the EPO response. This response is consistent with the proposed… CONTINUE READING
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