The feasibility of clinical endpoint trials in HIV infection in the highly active antiretroviral treatment (HAART) era

  title={The feasibility of clinical endpoint trials in HIV infection in the highly active antiretroviral treatment (HAART) era},
  author={Amanda Mocroft and James Neaton and Judith D. Bebchuk and S. Staszewski and F. Antunes and Brygida Knysz and Marc T. Law and Andrew N Phillips and Jens D. Lundgren},
  journal={Clinical Trials},
  pages={119 - 132}
  • Amanda Mocroft, James Neaton, +6 authors Jens D. Lundgren
  • Published in Clinical trials 2006
  • Medicine
  • Clinical Trials
  • Background Planning clinical-endpoint trials in patients with HIV remain difficult as long-term follow-up of many patients is required. Cohort studies of patients with HIV can provide key estimates of the likely disease progression, required sample size and follow-up. Objectives To verify the assumptions used in designing ESPRIT, a large randomized clinical trial assessing the clinical benefit of interleukin-2 treatment in patients with HIV infection, to use EuroSIDA to mimic the inclusion… CONTINUE READING

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