The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

@article{Mancini2013TheFA,
  title={The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?},
  author={Arturo D. Mancini and Vincent Poitout},
  journal={Trends in endocrinology and metabolism: TEM},
  year={2013},
  volume={24 8},
  pages={398-407}
}
Glucose homeostasis requires the highly coordinated regulation of insulin secretion by pancreatic β cells. This is primarily mediated by glucose itself, but other nutrients, including free fatty acids (FFAs), potentiate the insulinotropic capacity of glucose. A decade ago, the seven-transmembrane domain receptor (7TMR) GPR40 was demonstrated to be predominantly expressed in β cells and activated by long-chain FFAs. This discovery added a new dimension to our understanding of FFA-mediated… CONTINUE READING
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