The fate of the messenger is pre-determined: a new model for regulation of gene expression.

  title={The fate of the messenger is pre-determined: a new model for regulation of gene expression.},
  author={Gal Haimovich and Mordechai Choder and Robert H Singer and Tatjana Trcek},
  journal={Biochimica et biophysica acta},
  volume={1829 6-7},
Recent years have seen a rise in publications demonstrating coupling between transcription and mRNA decay. This coupling most often accompanies cellular processes that involve transitions in gene expression patterns, for example during mitotic division and cellular differentiation and in response to cellular stress. Transcription can affect the mRNA fate by multiple mechanisms. The most novel finding is the process of co-transcriptional imprinting of mRNAs with proteins, which in turn regulate… CONTINUE READING


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