The fate of the messenger is pre-determined: a new model for regulation of gene expression.

@article{Haimovich2013TheFO,
  title={The fate of the messenger is pre-determined: a new model for regulation of gene expression.},
  author={Gal Haimovich and Mordechai Choder and Robert H Singer and Tatjana Trcek},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1829 6-7},
  pages={643-53}
}
Recent years have seen a rise in publications demonstrating coupling between transcription and mRNA decay. This coupling most often accompanies cellular processes that involve transitions in gene expression patterns, for example during mitotic division and cellular differentiation and in response to cellular stress. Transcription can affect the mRNA fate by multiple mechanisms. The most novel finding is the process of co-transcriptional imprinting of mRNAs with proteins, which in turn regulate… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells

Proceedings of the National Academy of Sciences of the United States of America • 2017

References

Publications referenced by this paper.
Showing 1-10 of 174 references

Unr

T. C. Chang, A. Yamashita, +6 authors A. B. Shyu
a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant, Genes Dev. 18 • 2004
View 12 Excerpts
Highly Influenced

Dbf2

H. Y. Liu, J. H. Toyn, +3 authors C. L. Denis
a cell cycle-regulated protein kinase, is physically and functionally associated with the CCR4 transcriptional regulatory complex, EMBO J. 16 • 1997
View 6 Excerpts
Highly Influenced

Transcriptional activity regulates alternative cleavage and polyadenylation

Molecular systems biology • 2011
View 8 Excerpts
Highly Influenced

The Ccr4--not complex.

View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…