The fate of saccharin impurities: the metabolism and excretion of 3-amino [3-14C]benz[d]-isothiazole-1,1-dioxide and 5-chlorosaccharin in the rat.

@article{Renwick1978TheFO,
  title={The fate of saccharin impurities: the metabolism and excretion of 3-amino [3-14C]benz[d]-isothiazole-1,1-dioxide and 5-chlorosaccharin in the rat.},
  author={Andrew G. Renwick},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1978},
  volume={8 8},
  pages={
          487-94
        }
}
  • A. Renwick
  • Published 1978
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in biological systems
1. 3-Amino[3-14C]benz[d]isothiazole-1, 1-dioxide was prepared from [3-14C]-saccharin. IT was well adsorbed on oral administration to rats (25 mg/kg) with only 2% of the 14C in the faeces. The absorbed material was rapidly eliminated with about 87% dose in the urine in 24 h and 91% in 4 days. Little 14C (0.5% of dose) was present in the carcass 4 days after dosing. Most of the 14C in the 0--24 h urine (99%) was present as unchanged 3-aminobenz[d]isothiazole-1,1-dioxide, the rest being an… 
Saccharin and its salts.
  • Medicine
    IARC monographs on the evaluation of carcinogenic risks to humans
  • 1999
Saccharin Chem. Abstr. Serv. Reg. No.: 81-07-2 Deleted CAS Reg. Nos: 474-91-9; 61255-27-4; 126987-83-5 Chem. Abstr. Name: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide IUPAC Systematic Name:
Recent Advances in the Chemistry of Benzisothiazoles and Other Polycyclic Isothiazoles
Publisher Summary This chapter discusses the chemistry of benzisothiazoles and other polycyclic isothiazoles, and describes the formation of 1, 2-benzisothiazoles using mercaptophenyl aldehydes,

References

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The fate of saccharin impurities: the excretion and metabolism of [3-14C]Benz[d]-isothiazoline-1,1-dioxide (BIT) in man and rat.
TLDR
The 14C label of [3-14C]benz[d]isothiazoline-1,1-dioxide (BIT) was rapidly eliminated, largely in the urine, after oral administration to rats, and the possible significance of metabolic interrelationships of toluene-2-sulphonamide and BIT to studies on the metabolism of saccharin are discussed.
The fate of saccharin impurities. The excretion and metabolism of [14C]toluene-4-sulphonamide and 4-sulphamoyl[14C]benzoic acid in the rat.
1. 4-Sulphamoyl[carboxy-14C]benzoic acid was rapidly eliminateda after oral administration to rats (94% dose in 24 h). After 6 days most of the 14C (73-83% dose) was recovered in the urine with
The fate of saccharin impurities: the excretion and metabolism of toluene-2-sulphonamide in man and rat.
TLDR
Oral doses (20 mg/kg) of [Me-14C]toluene-2-sulphonamide were rapidly eliminated by rats and most of the 14C was recovered in the urine within 7 days with litte in the faeces.
The fate of [14C]saccharin in man, rat and rabbit and of 2-sulphamoyl[14C]benzoic acid in the rat.
TLDR
Saccharin given orally to rabbits kept on untreated water and on water containing 1% saccharin for 6 months was excreted unchanged, 60–80% in 24 h, with 70% in urine and 3–11% in faeces.
Das Massenspktroskopische Fragmentierungsverhalten von Derivaten des Benzisothiazol‐S‐dioxids
Das Fragmentierungsverhalten von Derivaten des Benzisothiazol-S-dioxids wird diskutiert. Es last sich fur die Verbindungsklasse eine Reihe von typischen Zerfallsreaktionen erkennen, deren relatives