The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation.

@article{Corona2006TheFO,
  title={The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation.},
  author={G R Leonel Corona and Xenofon Tzounis and M Assunta Dess{\`i} and Monica Deiana and Edward S. Debnam and Francesco Visioli and Jeremy P. E. Spencer},
  journal={Free radical research},
  year={2006},
  volume={40 6},
  pages={
          647-58
        }
}
We have conducted a detailed investigation into the absorption, metabolism and microflora-dependent transformation of hydroxytyrosol (HT), tyrosol (TYR) and their conjugated forms, such as oleuropein (OL). Conjugated forms underwent rapid hydrolysis under gastric conditions, resulting in significant increases in the amount of free HT and TYR entering the small intestine. Both HT and TYR transferred across human Caco-2 cell monolayers and rat segments of jejunum and ileum and were subject to… CONTINUE READING

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