The fate of naringin in humans: a key to grapefruit juice-drug interactions?

@article{Fuhr1995TheFO,
  title={The fate of naringin in humans: a key to grapefruit juice-drug interactions?},
  author={Uwe Fuhr and Anton Kummert},
  journal={Clinical pharmacology and therapeutics},
  year={1995},
  volume={58 4},
  pages={365-73}
}
The increase of concentrations observed for many drugs when administered concomitantly with grapefruit juice was attributed to inhibition of cytochrome P450 enzymes by naringenin, the aglycone of the grapefruit flavonoid naringin. However, this explanation is equivocal, and formation of naringenin after ingestion of grapefruit juice has not been proved. We investigated renal excretion of naringin, naringenin, and its glucuronides after administration of 20 ml grapefruit juice (621 mumol/L… CONTINUE READING

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