The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation.

@article{Lee2005TheFO,
  title={The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation.},
  author={Lisa M J Lee and Elisabeth A. Seftor and Gregory Bonde and Robert A Cornell and Mary J. C. Hendrix},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2005},
  volume={233 4},
  pages={1560-70}
}
Certain aggressive melanoma cell lines exhibit a dedifferentiated phenotype, expressing genes that are characteristic of various cell types including endothelial, neural, and stem cells. Moreover, we have shown that aggressive melanoma cells can participate in neovascularization in vivo and vasculogenic mimicry in vitro, demonstrating that these cells respond to microenvironmental cues and manifest developmental plasticity. To explore this plasticity further, we transplanted human metastatic… CONTINUE READING