The fate of competing beneficial mutations in an asexual population

@article{Gerrish1998TheFO,
  title={The fate of competing beneficial mutations in an asexual population},
  author={Philip J. Gerrish and Richard E. Lenski},
  journal={Genetica},
  year={1998},
  volume={102-103},
  pages={127-144}
}
In sexual populations, beneficial mutations that occur in different lineages may be recombined into a single lineage. In asexual populations, however, clones that carry such alternative beneficial mutations compete with one another and, thereby, interfere with the expected progression of a given mutation to fixation. From theoretical exploration of such ‘clonal interference’, we have derived (1) a fixation probability for beneficial mutations, (2) an expected substitution rate, (3) an expected… CONTINUE READING
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