The fate of cell grafts for the treatment of Huntington's disease: the post-mortem evidence.

@article{Cisbani2014TheFO,
  title={The fate of cell grafts for the treatment of Huntington's disease: the post-mortem evidence.},
  author={Giulia Cisbani and Francesca Cicchetti},
  journal={Neuropathology and applied neurobiology},
  year={2014},
  volume={40 1},
  pages={71-90}
}
The hope that cell transplantation therapies will provide an ideal treatment option for neurodegenerative diseases has been considerably revived with the remarkable advancements in genetic engineering towards active cell fate determination in vitro. However, for disorders such as Huntington's disease (HD), the challenges that we face are still enormous. This autosomal dominant genetic disorder leads, in part, to massive neuronal loss and severe brain atrophy which, despite the cell type used… CONTINUE READING