The fate of ZnO nanoparticles administered to human bronchial epithelial cells.

@article{Gilbert2012TheFO,
  title={The fate of ZnO nanoparticles administered to human bronchial epithelial cells.},
  author={Benjamin Gilbert and Sirine C. Fakra and Tian Xia and Suman Pokhrel and Lutz M{\"a}dler and Andr{\'e} E Nel},
  journal={ACS nano},
  year={2012},
  volume={6 6},
  pages={4921-30}
}
A particular challenge for nanotoxicology is the evaluation of the biological fate and toxicity of nanomaterials that dissolve in aqueous fluids. Zinc oxide nanomaterials are of particular concern because dissolution leads to release of the toxic divalent zinc ion. Although zinc ions have been implicated in ZnO cytotoxicity, direct identification of the chemical form of zinc taken up by cells exposed to ZnO nanoparticles, and its intracellular fate, has not yet been achieved. We combined high… CONTINUE READING