The fate of P2Y-related orphan receptors: GPR80/99 and GPR91 are receptors of dicarboxylic acids

  title={The fate of P2Y-related orphan receptors: GPR80/99 and GPR91 are receptors of dicarboxylic acids},
  author={N. S. Gonzalez and D. Communi and S{\'e}bastien Hannedouche and J. Boeynaems},
  journal={Purinergic Signalling},
  pages={17 - 20}
Several orphan G protein-coupled receptors are structurally close to the family of P2Y nucleotide receptors: GPR80/99 and GPR91 are close to P2Y1/2/4/6/11 receptors, whereas GPR87, H963 and GPR34 are close to P2Y12/13/14. Over the years, several laboratories have attempted without success to identify the ligands of those receptors. In early 2004, two papers have been published: One claiming that GPR80/99 is an AMP receptor, called P2Y15, and the other one showing that GPR80/99 is a receptor for… Expand
19 Citations

Paper Mentions

Interventional Clinical Trial
- The G coupled-protein receptors 99 (GPR99) was discovered in 2002 by Wittenberg et al. and is involved as a metabolic receptor. It has been shown that the natural ligand of… Expand
ConditionsAcid Base Disorder
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Discovery of a potent and selective small molecule hGPR91 antagonist.
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Discovery and mapping of ten novel G protein-coupled receptor genes.
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A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor.
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Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
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