The fate of P2Y-related orphan receptors: GPR80/99 and GPR91 are receptors of dicarboxylic acids

@article{Gonzalez2004TheFO,
  title={The fate of P2Y-related orphan receptors: GPR80/99 and GPR91 are receptors of dicarboxylic acids},
  author={N. S. Gonzalez and D. Communi and S{\'e}bastien Hannedouche and J. Boeynaems},
  journal={Purinergic Signalling},
  year={2004},
  volume={1},
  pages={17 - 20}
}
Several orphan G protein-coupled receptors are structurally close to the family of P2Y nucleotide receptors: GPR80/99 and GPR91 are close to P2Y1/2/4/6/11 receptors, whereas GPR87, H963 and GPR34 are close to P2Y12/13/14. Over the years, several laboratories have attempted without success to identify the ligands of those receptors. In early 2004, two papers have been published: One claiming that GPR80/99 is an AMP receptor, called P2Y15, and the other one showing that GPR80/99 is a receptor for… Expand
19 Citations

Paper Mentions

Interventional Clinical Trial
- The G coupled-protein receptors 99 (GPR99) was discovered in 2002 by Wittenberg et al. and is involved as a metabolic receptor. It has been shown that the natural ligand of… Expand
ConditionsAcid Base Disorder
InterventionOther
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
  • 1,130
  • Highly Influenced
  • PDF
Insight into SUCNR1 (GPR91) structure and function.
  • 53
  • PDF
GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding
  • 38
  • PDF
Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors
  • 18
Discovery of a potent and selective small molecule hGPR91 antagonist.
  • 43
Novel Agonists and Antagonists of Platelet Receptors
  • PDF
Succinate independently stimulates full platelet activation via cAMP and phosphoinositide 3‐kinase‐β signaling
  • 26
...
1
2
...

References

SHOWING 1-10 OF 23 REFERENCES
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids*
  • 1,436
  • PDF
Discovery and mapping of ten novel G protein-coupled receptor genes.
  • 174
A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor.
  • 130
  • PDF
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
  • 605
  • PDF
...
1
2
3
...