The fate of Drotaverine-Acephyllinate in rat and man II. Human pharmacokinetics of Drotaverine-14C-Acephyllinate

@article{Vargay1984TheFO,
  title={The fate of Drotaverine-Acephyllinate in rat and man II. Human pharmacokinetics of Drotaverine-14C-Acephyllinate},
  author={Z. Vargay and Tibor Deutsch and Istv{\'a}n Szatm{\'a}ri and T. Sz{\"u}ts and Peter Varkonyi and S{\'a}ndor Kerpel-Fronius and S{\'a}ndor Eckhardt},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={1984},
  volume={9},
  pages={17-29}
}
Pharmacokinetics of Drotaverine-Acephyllinate, Chinoin was investigated in seven male volunteers using14C labelled drug. Drotaverine-Acephyllinate was administered at a 100 mg single oral dose. Measurements of total radioactivity showed that the drug was absorbed completely and was eliminated by renal and biliary routes. Within 72 hours 39.9 ± 9.9% and 47.1 ± 4.9% of the dose were recovered in the urine and faeces respectively. Experimental results were interpreted on the basis of a complex… CONTINUE READING
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