• DOI:10.1007/BF03190451
• Corpus ID: 30618267

The fate of (−)1-(benzofuran-2-yl)-2-propylaminopentane · HCl, (−)-BPAP, in rats, a potent enhancer of the impulse-evoked release of catecholamines and serotonin in the brain

@article{Magyar2010TheFO,
  title={The fate of (−)1-(benzofuran-2-yl)-2-propylaminopentane · HCl, (−)-BPAP, in rats, a potent enhancer of the impulse-evoked release of catecholamines and serotonin in the brain},
  author={K{\'a}lm{\'a}n Magyar and J{\'o}zsef Lengyel and Andrea Bolehovszky and Bertha Knoll and Iidik{\'o} Miklya and Joseph Knoll},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={2010},
  volume={27},
  pages={157-161}
}

• K. Magyar, J. Lengyel, +3 authors J. Knoll
• Published 1 July 2002
• Medicine, Biology
• European Journal of Drug Metabolism and Pharmacokinetics

SummaryOur aim was to study the fate of (−)-1-(benzofuran-2-yl)-2-propylaminopentane · HCl [(−)-BPAP] in rats, using radio-labelled compound [(−)-BPAP-14C]. Radioactivity was measured by liquid scintillation technique and the tissue concentrations of radioactivity were calculated on the basis of the specific activity of (−)-BPAP-14C and the values are given in ngeq./g.Radioactivity was well absorbed after i.p., s.c. and oral treatment and Cmax has been reached at 30 to 60 min following drug administration. A second peak, detected at 4 hours, indicated enterohepatic circulation of the substance. The highest tissue levels of radioactivity were reached at 30 min following s.c. treatment. The time-related changes of radioactivity were measured in nine selected brain regions after s.c. administration of (−)-BPAP-14C. A similar distribution profile was observed in the brain regions with a peak level at 30 min. Radioactivity is preferentially eliminated through the urine, the secondary route of excretion was the stool. More than 90% of the substance was recovered in the excreta during 72 hours. The t1/2β was found to be 5.5 to 5.8 hours. (−)-BPAP was well absorbed and penetrated the brain. Its elimination was fast and enterohepatic circulation was observed in rats.