The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation.

@article{Ma2009TheFF,
  title={The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation.},
  author={Hansong Ma and Ferry Hagen and Dov J. Stekel and Simon Andrew Johnston and Edward Sionov and Rama Falk and Itzhack Polacheck and Teun Boekhout and Robin C May},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 31},
  pages={12980-5}
}
In 1999, the population of Vancouver Island, Canada, began to experience an outbreak of a fatal fungal disease caused by a highly virulent lineage of Cryptococcus gattii. This organism has recently spread to the Canadian mainland and Pacific Northwest, but the molecular cause of the outbreak remains unknown. Here we show that the Vancouver Island outbreak (VIO) isolates have dramatically increased their ability to replicate within macrophages of the mammalian immune system in comparison with… CONTINUE READING

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