The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

  title={The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry},
  author={Martin E. Hess and Simon Hess and Kate D. Meyer and Linda A. W. Verhagen and Linda Koch and Hella S. Br{\"o}nneke and Marcelo O. Dietrich and Sabine D. Jordan and Yogesh Saletore and Olivier Elemento and Bengt F. Belgardt and Thomas Franz and Tamas L. Horvath and Ulrich R{\"u}ther and Samie R. Jaffrey and Peter Kloppenburg and Jens C. Br{\"u}ning},
  journal={Nature Neuroscience},
Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like receptor')-dependent control of neuronal activity and behavioral responses. Conventional and DA neuron–specific Fto knockout mice show attenuated activation of G protein–coupled inwardly… 

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Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

It is reported that expression of the fat mass and obesity associated gene (FTO) is downregulated in the hippocampus of patients with MDD and mouse models of depression, suggesting that FTO is a regulator of a mechanism underlying depression-like behavior in mice.

Valproate-Induced Epigenetic Upregulation of Hypothalamic Fto Expression Potentially Linked with Weight Gain

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Hypomorphism of Fto and Rpgrip1l causes obesity in mice.

The results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the results of these genetic variations on hypothalamic FTO, RPGRIP1L, and possibly other genes.

Changes in Gene Expression Associated with FTO Overexpression in Mice

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Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions

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The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

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High-fat Feeding Promotes Obesity via Insulin Receptor/PI3k-Dependent Inhibition of SF-1 VMH Neurons

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D dopamine receptor classification, their basic structural and genetic organization, their distribution and functions in the brain and the periphery, and their regulation and signal transduction mechanisms are discussed.

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Brain dopamine and obesity

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