The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

@article{Yamauchi2001TheFH,
  title={The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity},
  author={Toshimasa Yamauchi and Junji Kamon and Hironori Waki and Yasuo Terauchi and Naoto Kubota and Kazuo Hara and Yasumichi Mori and Tomohiro Ide and Koji Murakami and Nobuyo Tsuboyama-Kasaoka and Osamu Ezaki and Yauso Akanuma and Oksana Gavrilova and Charles R. Vinson and M. L. Reitman and Hiroyuki Kagechika and Koyo Shudo and M. Yoda and Yasuko Nakano and Kazuyuki Tobe and Ryozo Nagai and Satoshi Kimura and Motoo Tomita and Philippe Froguel and Takashi Kadowaki},
  journal={Nature Medicine},
  year={2001},
  volume={7},
  pages={941-946}
}
Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where the gene encoding adiponectin is located. Here we show that decreased expression of adiponectin correlates with insulin resistance in mouse models of altered insulin sensitivity. Adiponectin decreases insulin resistance by decreasing triglyceride content in muscle and liver in obese mice. This effect results from increased… 
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TLDR
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TLDR
Data show adiponectin to be an important factor in the issue of obesity and its associated disorders, and indicate a potential future utilization of adip onectin as a drug in the treatment of metabolic syndrome.
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TLDR
Evaluation of adiponectin receptor as a target of diabetes (insulin resistance), obesity and atherosclerosis and asthma is evaluated and potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance are considered.
Adiponectin in insulin resistance: lessons from translational research.
TLDR
Studies to date provide promising results for the diagnostic and therapeutic role of adiponectin in obesity, insulin resistance, diabetes, cardiovascular disease, and obesity-associated malignancies.
Role of adiponectin system in insulin resistance.
  • C. Caselli
  • Biology, Medicine
    Molecular genetics and metabolism
  • 2014
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