The fastest contracting muscles of nonmammalian vertebrates express only one isoform of the ryanodine receptor.

@article{OBrien1993TheFC,
  title={The fastest contracting muscles of nonmammalian vertebrates express only one isoform of the ryanodine receptor.},
  author={Jennifer H O'Brien and Gerhard Meissner and Barbara A Block},
  journal={Biophysical journal},
  year={1993},
  volume={65 6},
  pages={2418-27}
}
The skeletal muscles of chickens, frogs, and fish have been reported to express two isoforms (alpha and beta) of the sarcoplasmic reticulum calcium release channel (ryanodine receptor or RYR), while mammals express only one. We have studied patterns of RYR isoform expression in skeletal muscles from a variety of fish, reptiles, and birds with immunological techniques. Immunoblot analysis with a monoclonal antibody that recognizes both nonmammalian RYR isoforms and a polyclonal antibody specific… CONTINUE READING