The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.

@article{Qiu2007TheFI,
  title={The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.},
  author={Yuanzheng Qiu and Xiangguo Liu and Wei Zou and Ping Yue and Sagar Lonial and Fadlo R. Khuri and Shi-yong R Sun},
  journal={Cancer research},
  year={2007},
  volume={67 10},
  pages={4973-80}
}
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in transformed or malignant cells, thus exhibiting potential as a tumor-selective apoptosis-inducing cytokine for cancer treatment. Many studies have shown that the apoptosis-inducing activity of TRAIL can be enhanced by various cancer therapeutic agents… CONTINUE READING