The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution

Abstract

BACKGROUND Growth inhibition by RPR-130401, a non-peptidomimetic farnesyltransferase inhibitor, was investigated without or with combined exposure to ionizing radiation in three human tumor cell lines (HCT-116, MiAPaCa-2 and A-549) bearing a point mutation in the K-Ras gene. RESULTS RPR-130401 inhibited cell growth with an IC50 of 50 nM (HCT-116), 120 nM… (More)

Topics

7 Figures and Tables

Slides referencing similar topics