The farnesoid X-receptor is an essential regulator of cholesterol homeostasis.

  title={The farnesoid X-receptor is an essential regulator of cholesterol homeostasis.},
  author={Gilles Lambert and Marcelo J Amar and Grace L. Guo and Hollis B Brewer and Frank J. Gonzalez and Christopher J. Sinal},
  journal={The Journal of biological chemistry},
  volume={278 4},
To address the importance of the farnesoid X-receptor (FXR; NR1H4) for normal cholesterol homeostasis, we evaluated the major pathways of cholesterol metabolism in the FXR-deficient (-/-) mouse model. Compared with wild-type, FXR(-/-) mice have increased plasma high density lipoprotein (HDL) cholesterol and a markedly reduced rate of plasma HDL cholesterol ester clearance. Concomitantly, FXR(-/-) mice exhibit reduced expression of hepatic genes involved in reverse cholesterol transport, most… CONTINUE READING
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