The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression.

@article{Urizar2000TheFX,
  title={The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression.},
  author={Nancy L Urizar and Dennis H. Dowhan and David D. Moore},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 50},
  pages={39313-7}
}
Bile acids facilitate the absorption of dietary lipids and fat-soluble vitamins and are physiological ligands for the farnesoid X-activated receptor (FXR), a member of the nuclear hormone receptor superfamily. FXR functions as a heterodimer with the retinoid X receptor and in the presence of ligand, the heterodimer binds to specific DNA sequences in the promoters of target genes to regulate gene transcription. Phospholipid transfer protein (PLTP) has been identified as a possible target gene… CONTINUE READING