The family of ubiquitin‐conjugating enzymes (E2s): deciding between life and death of proteins

  title={The family of ubiquitin‐conjugating enzymes (E2s): deciding between life and death of proteins},
  author={Sjoerd J. L. van Wijk and H. Th. Marc Timmers},
  journal={The FASEB Journal},
  pages={981 - 993}
The family of ubiquitin‐conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin‐conjugating (UBC) domain. These domains accommodate the ATP‐activated ubiquitin (Ub) or ubiquitin‐like (UBL) protein via a covalently linked thioester onto its active‐site residue. E2 enzymes act via selective protein‐protein interactions with the E1 αnd E3 enzymes and connect activation to covalent modification. By doing so, E2s differentiate effects on downstream substrates… 

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