The family of thiol-activated, cholesterol-binding cytolysins.

  title={The family of thiol-activated, cholesterol-binding cytolysins.},
  author={Michael Palmer},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={39 11},
  • Michael Palmer
  • Published 2001 in
    Toxicon : official journal of the International…
Several species of both pathogenic and non-pathogenic grampositive bacteria within the genera Streptococcus, Clostridium and Bacillus secrete cytolytic proteins that belong to a single, highly homologous family. The most widely known members of this family are streptolysin O, listeriolysin, perfringolysin, and pneumolysin. These toxins specifically require membrane cholesterol but, apparently, do not depend on any other specific cell surface receptor, so that they are able to lyse the… CONTINUE READING

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