The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes.

@article{Grtzinger1997TheFO,
  title={The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes.},
  author={Joachim Gr{\"o}tzinger and Guenther Kurapkat and Axel Wollmer and M Kalai and Stefan Rose-John},
  journal={Proteins},
  year={1997},
  volume={27 1},
  pages={96-109}
}
The cytokines IL-6, LIF, CNTF, OSM, IL-11, and CT-1 have been grouped into the family of IL-6-type cytokines, since they all require gp130 for signal transduction. Interestingly, gp130 binds directly to OSM, whereas complex formation with the other cytokines depends on additional receptor subunits. Only limited structural information on these cytokines and their receptors is available. X-ray structures have been solved for the cytokines LIF and CNTF, whose up-up-down-down four-helix bundle is… CONTINUE READING

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