The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.

@article{Seidah1994TheFO,
  title={The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.},
  author={Nabil G Seidah and Michel Chr{\'e}tien and Robert Day},
  journal={Biochimie},
  year={1994},
  volume={76 3-4},
  pages={
          197-209
        }
}
Six mammalian processing enzymes were recently discovered which exhibit significant similarities to both yeast kexin and bacterial subtilisins. These subtilisin/kexin-like convertases were called furin/PACE, PC1/PC3, PC2, PACE4, PC4 and PC5/PC6. The analysis of the mRNA expression of these convertases in rat tissues and cell lines by Northern blot analysis demonstrated a unique pattern for each enzyme. Thus, although furin and PACE4 mRNA (4.4 kb each) exhibit a widespread tissue distribution… CONTINUE READING
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