The family of K2P channels: salient structural and functional properties.

  title={The family of K2P channels: salient structural and functional properties.},
  author={Sylvain F. Feliciangeli and Frank C Chatelain and Delphine Bichet and Florian Lesage},
  journal={The Journal of physiology},
  volume={593 12},
Potassium channels participate in many biological functions, from ion homeostasis to generation and modulation of the electrical membrane potential. They are involved in a large variety of diseases. In the human genome, 15 genes code for K(+) channels with two pore domains (K2P ). These channels form dimers of pore-forming subunits that produce background conductances finely regulated by a range of natural and chemical effectors, including signalling lipids, temperature, pressure, pH… CONTINUE READING
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