The family feud: turning off Sp1 by Sp1-like KLF proteins.

  title={The family feud: turning off Sp1 by Sp1-like KLF proteins.},
  author={Gwen A. Lomberk and Raul A Urrutia},
  journal={The Biochemical journal},
  volume={392 Pt 1},
Sp1 is one of the best characterized transcriptional activators. The biological importance of Sp1 is underscored by the fact that several hundreds of genes are thought to be regulated by this protein. However, during the last 5 years, a more extended family of Sp1-like transcription factors has been identified and characterized by the presence of a conserved DNA-binding domain comprising three Krüppel-like zinc fingers. Each distinct family member differs in its ability to regulate… CONTINUE READING

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