The fallopian tube: primary site of most pelvic high-grade serous carcinomas.

@article{Salvador2009TheFT,
  title={The fallopian tube: primary site of most pelvic high-grade serous carcinomas.},
  author={Shannon C Salvador and Blake C. Gilks and Martin K{\"o}bel and David Huntsman and Barry Rosen and Dianne Miller},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2009},
  volume={19 1},
  pages={
          58-64
        }
}
Epithelial ovarian cancer is the most common cause of mortality from gynecologic malignancy, and most of epithelial cancers are of serous type. The site of origin of pelvic high-grade serous carcinoma has been the subject of debate for 60 years. This paper reviews the evidence that pelvic serous carcinoma originates from the fallopian tube mucosa and puts forward a theory that inflammation in the tube, caused by menstrual cytokines or infection, is critical to the genesis of these tumors. Other… CONTINUE READING

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