The factor time in acute intravenous toxicity studies of contrast media.

@article{deHan1994TheFT,
  title={The factor time in acute intravenous toxicity studies of contrast media.},
  author={Christoph de Ha{\"e}n and Alberto Morisetti and F Bertani and Piero Tirone},
  journal={Investigative radiology},
  year={1994},
  volume={29 Suppl 2},
  pages={
          S108-10
        }
}
Gadolinium contrast media are more nephrotoxic than iodine media. The importance of osmolality in direct renal artery injections
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Reduction in GFR, as a marker of nephrotoxicity, induced by gadopentetate correlated with its high osmolality, while the effect of gadodiamide and iohexol may include chemotoxicity.
Gadolinium contrast media are more nephrotoxic than iodine media. The importance of osmolality in direct renal artery injections
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The results of the saline group are from a previous investigation, but where the GFR marker iohexol (3 ml, 300 mg I/ml) were injected intravenously and could as such be used to calculate the volume of distribution of io hexol (see the present discussion).
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The current chapter aims to provide an overview on the main topics related to MRI contrast agents including the mechanisms of MRI contrast and contrast agents, classification of both commercially available and preclinically investigational contrast agents useful for cardiac MRI, as well as the general scope of contrast agent applications in relevant clinical practice and experimental research.
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Clinical experience has shown that the physiological parameters often stay closer to baseline alter Visipaque than after administration of conventional CM, and overall tolerance to the new dimeric compound iodixanol (Visipaque), representing the latest step in the development of CM, has been shown to be higher than to tire nonionic monomers.
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