The eye-of-the-tiger sign is not a reliable disease marker for Hallervorden-Spatz syndrome.

@article{Baumeister2005TheES,
  title={The eye-of-the-tiger sign is not a reliable disease marker for Hallervorden-Spatz syndrome.},
  author={Friedrich Albert Matthias Baumeister and D P Auer and Konstanze H{\"o}rtnagel and Peter Freisinger and Thomas Meitinger},
  journal={Neuropediatrics},
  year={2005},
  volume={36 3},
  pages={221-2}
}
Pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome, is a rare autosomal recessive disorder characterized by extrapyramidal dysfunction as demonstrated by dystonia, rigidity, and choreoathetosis. Iron deposition in conjunction with destruction of the globus pallidus gives rise to the characteristic eye-of-the-tiger sign in MRI. It has been postulated that pantothenate kinase 2 mutations underlying all cases of classic Hallervorden-Spatz syndrome are… CONTINUE READING

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