The eye as a model of ageing in translational research – Molecular, epigenetic and clinical aspects

@article{Pathai2013TheEA,
  title={The eye as a model of ageing in translational research – Molecular, epigenetic and clinical aspects},
  author={Sophia Pathai and Paul G Shiels and Stephen D. Lawn and Colin Cook and Clare E Gilbert},
  journal={Ageing Research Reviews},
  year={2013},
  volume={12},
  pages={490-508}
}
The eye and visual system are valuable in many areas of translational research such as stem cell therapy, transplantation research and gene therapy. Changes in many ocular tissues can be measured directly, easily and objectively in vivo (e.g. lens transparency; retinal blood vessel calibre; corneal endothelial cell counts) and so the eye may also be a uniquely useful site as a model of ageing. This review details cellular, molecular and epigenetic mechanisms related to ageing within the eye… Expand
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