The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils.

@article{Adachi2014TheEN,
  title={The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils.},
  author={Emi Adachi and Asako Kosaka and Kohei Tsuji and Chiharu Mizuguchi and Hiroyuki Kawashima and Akira Shigenaga and Kohjiro Nagao and Kenichi Akaji and Akira Otaka and Hiroyuki Saito},
  journal={FEBS letters},
  year={2014},
  volume={588 3},
  pages={389-94}
}
The N-terminal 1-83 residues of apolipoprotein A-I (apoA-I) have a strong propensity to form amyloid fibrils, in which the 46-59 segment was reported to aggregate to form amyloid-like fibrils. In this study, we demonstrated that a fragment peptide comprising the extreme N-terminal 1-43 residues strongly forms amyloid fibrils with a transition to β-sheet-rich structure, and that the G26R point mutation enhances the fibril formation of this segment. Our results suggest that in addition to the 46… CONTINUE READING
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