The extraneuronal transport mechanism for noradrenaline (uptake2) avidly transports 1-methyl-4-phenylpyridinium (MPP+)

@article{Russ1992TheET,
  title={The extraneuronal transport mechanism for noradrenaline (uptake2) avidly transports 1-methyl-4-phenylpyridinium (MPP+)},
  author={Hermann Russ and Martin Gliese and J. Sonna and Edgar Sch{\"o}mig},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1992},
  volume={346},
  pages={158-165}
}
SummaryThe corticosterone-sensitive extraneuronal transport mechanism for noradrenaline (uptake2) removes the neurotransmitter from the extracellular space. Recently, an experimental model for uptake2 has been introduced which is based on tissue culture techniques (human Caki-1 cells). The present study describes some properties of uptake2 in Caki-1 cells and introduces a new substrate, i.e., 1-methyl-4-phenylpyridinium (MPP+).Experiments on Caki-1 cells disclosed disadvantages of tritiated… CONTINUE READING
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