The extradomain A of fibronectin (EDA) combined with poly(I:C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model.

@article{Romn2012TheEA,
  title={The extradomain A of fibronectin (EDA) combined with poly(I:C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model.},
  author={Beatriz San Rom{\'a}n and Ximena de Andr{\'e}s and Pilar Munoz and Patricia Obreg{\'o}n and Aaron-C Asensio and Victoria G. Garrido and Cristina Mansilla and Laura Arribillaga and Juan J Lasarte and Dami{\'a}n de Andr{\'e}s and Beatriz Amorena and M J Grill{\'o}},
  journal={Vaccine},
  year={2012},
  volume={30 15},
  pages={2564-9}
}
The development of effective vaccines against HIV-1 infection constitutes one of the major challenges in viral immunology. One of the protein candidates in vaccination against this virus is p24, since it is a conserved HIV antigen that has cytotoxic and helper T cell epitopes as well as B cell epitopes that may jointly confer enhanced protection against infection when used in immunization-challenge approaches. In this context, the adjuvant effect of EDA (used as EDAp24 fusion protein) and poly… CONTINUE READING