The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration.

@article{Rossi2007TheEN,
  title={The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration.},
  author={Lara Rossi and Rossella Manfredini and Francesco Bertolini and Davide Ferrari and M. Fogli and Roberta Zini and Simona Salati and Valentina Salvestrini and Sara Gulinelli and E Adinolfi and Sergio Ferrari and Francesco Di Virgilio and Michele Baccarani and Roberto Massimo Lemoli},
  journal={Blood},
  year={2007},
  volume={109 2},
  pages={533-42}
}
Homing and engraftment of hematopoietic stem cells (HSCs) to the bone marrow (BM) involve a complex interplay between chemokines, cytokines, and nonpeptide molecules. Extracellular nucleotides and their cognate P2 receptors are emerging as key factors of inflammation and related chemotactic responses. In this study, we investigated the activity of extracellular adenosine triphosphate (ATP) and uridine triphosphate (UTP) on CXCL12-stimulated CD34+ HSC chemotaxis. In vitro, UTP significantly… CONTINUE READING