The extracellular matrix in axon regeneration.

  title={The extracellular matrix in axon regeneration.},
  author={Barbara Grimpe and Jerry Silver},
  journal={Progress in brain research},
This review of ECM molecules shows quite clearly the function of the ECM in development but more importantly in the mature CNS after injury. Most of the proteoglycans, especially the large CS-PGs, are able to inhibit neurite outgrowth and in vivo experiments are now in progress to specifically inhibit these important molecules. The nature of growth promoter ECM molecules in the CNS after injury, either within or distant from the injury is now becoming better appreciated and we suggest that the… CONTINUE READING