The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration.

@article{Chen2010TheEM,
  title={The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration.},
  author={J. H. Chen and Hyun Joon Lee and Igor Jakov{\vc}evski and Ronak Shah and Neha D Bhagat and Gabriele Loers and Hsing-Yin Liu and Sally Meiners and Grit Taschenberger and Sebastian K{\"u}gler and Andrey Irintchev and Melitta Schachner},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2010},
  volume={18 10},
  pages={1769-77}
}
Tenascin-C (TNC), a major component of the extracellular matrix, is strongly upregulated after injuries of the central nervous system (CNS) but its role in tissue repair is not understood. Both regeneration promoting and inhibiting roles of TNC have been proposed considering its abilities to both support and restrict neurite outgrowth in vitro. Here, we show that spontaneous recovery of locomotor functions after spinal cord injury is impaired in adult TNC-deficient (TNC(-/-)) mice in comparison… CONTINUE READING