The extracellular matrix glycoprotein elastin microfibril interface located protein 2: a dual role in the tumor microenvironment.

@article{Mongiat2010TheEM,
  title={The extracellular matrix glycoprotein elastin microfibril interface located protein 2: a dual role in the tumor microenvironment.},
  author={Maurizio Mongiat and Stefano Marastoni and Giovanni Ligresti and Erica Lorenzon and Monica Schiappacassi and Roberto Perris and Sergio Frustaci and Alfonso Colombatti},
  journal={Neoplasia},
  year={2010},
  volume={12 4},
  pages={
          294-304
        }
}
We have recently reported that elastin microfibril interface located protein 2 (EMILIN2), an extracellular matrix (ECM) glycoprotein, triggers cell death through a direct binding to death receptors. EMILIN2 thus influences cell viability through a mechanism that is unique for an ECM molecule. In the present work, we report an additional function for this molecule. First, we identify the region responsible for the proapoptotic effects, a 90-amino acid residue-long coiled-coil fragment toward the… CONTINUE READING
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