The extracellular matrix differentially regulates the expression of PTHrP and the PTH/PTHrP receptor in FG pancreatic cancer cells.

@article{Grzesiak2004TheEM,
  title={The extracellular matrix differentially regulates the expression of PTHrP and the PTH/PTHrP receptor in FG pancreatic cancer cells.},
  author={John J Grzesiak and Paul C Clopton and Cheryl Chalberg and Kathy C Smith and Douglas W. Burton and Steve A. Silletti and Abdool R. Moossa and Leonard John Deftos and Michael Bouvet},
  journal={Pancreas},
  year={2004},
  volume={29 2},
  pages={85-92}
}
OBJECTIVES Previous studies by our laboratory have demonstrated that parathyroid hormone-related protein (PTHrP) and its receptor (PTH/PTHrP receptor) are commonly expressed in pancreatic cancer and suggest their participation in the progression of this devastating disease. It has also been demonstrated that one of the major hallmarks of pancreatic adenocarcinoma is an increased production of the extracellular matrix (ECM), a critical regulator of diverse cellular processes such as… CONTINUE READING