The extracellular matrix as an adhesion checkpoint for mammary epithelial function

@inproceedings{Katz2007TheEM,
  title={The extracellular matrix as an adhesion checkpoint for mammary epithelial function},
  author={Elad Katz and Charles H Streuli},
  booktitle={The international journal of biochemistry & cell biology},
  year={2007}
}
The development of the mammary gland is spatially regulated by the interaction of the mammary epithelium with the extracellular matrix (ECM). Cells receive cues from the ECM through a family of adhesion receptors called integrins, consisting of alpha- and beta-chain dimers. Integrins assist cells in sensing their appropriate developmental context in response to both hormones and growth factors. Here we argue that cell adhesion to the ECM plays a key role in specific developmental checkpoints… CONTINUE READING

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