The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand

@article{Chakrabandhu2008TheEG,
  title={The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand},
  author={Krittalak Chakrabandhu and S{\'e}bastien Huault and Nicolas Garmy and Jacques Fantini and Emmanuelle Stebe and S{\'e}bastien Mailfert and Didier Marguet and A-O Hueber},
  journal={Cell Death and Differentiation},
  year={2008},
  volume={15},
  pages={1824-1837}
}
Selective compartmentalization and internalization have been shown as a means for regulating specific signals of cell surface receptors to correspond to cellular requirements and conditions. Here, we present a conserved extracellular glycosphingolipid-binding motif of Fas as one of the regulatory elements in the selection of its internalization route and consequently the signals transmitted upon ligand binding. This motif is required for clathrin-mediated internalization of Fas, which allows… CONTINUE READING
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