The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design.

@article{Zhang2000TheED,
  title={The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design.},
  author={Mingchang Zhang and K P Tong and Val{\'e}rie Fr{\'e}mont and Jing Chen and Prema Narayan and David Puett and Bruce D. Weintraub and Mariusz W. Szkudlinski},
  journal={Endocrinology},
  year={2000},
  volume={141 9},
  pages={3514-7}
}
Among glycoprotein hormone receptors the TSH receptor (TSHR) is the most susceptible to constitutive activation by mutations in various regions of the molecule, including mutations in the extracellular domain (ECD) and extracellular loops of the transmembrane domain (TMD). To understand the role of the ECD in TSHR activation we have tested several TSHR constructs with major deletions of the ECD. Previous studies reported very low expression of such truncated glycoprotein hormone receptors… CONTINUE READING

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