The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A).

@article{Justinich2008TheEC,
  title={The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A).},
  author={Christopher J. Justinich and Nanette Mak and Ivan Pacheco and Dan Mulder and Ron W. Wells and M G Blennerhassett and R. John Macleod},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={294 1},
  pages={G120-9}
}
Gastrointestinal reflux disease and eosinophilic esophagitis are characterized by basal cell hyperplasia. The extracellular calcium-sensing receptor (CaSR), a G protein-coupled receptor, which may be activated by divalent agonists, is expressed throughout the gastrointestinal system. The CaSR may regulate proliferation or differentiation, depending on cell type and tissue. The current experiments demonstrate the expression of the CaSR on a human esophageal epithelial cell line (HET-1A) and the… CONTINUE READING

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